Holding a mysterious leather suitcase in his hand, Newt Scamander, a young activist wizard from England, visits New York while he is on his way to Arizona.
Inside his expanding suitcase hides a wide array of diverse, magical creatures that exist among us, ranging from tiny, twig-like ones, to majestic and humongous ones.
It is the middle of the 20s and times are troubled since the already fragile equilibrium of secrecy between the unseen world of wizards and the ordinary or "No-Maj" people that the MACUSA Congress struggles to maintain, is at risk of being unsettled.
In the meantime, the voices against wizardry keep growing with daily protests led by Mary Lou Barebone and fuelled by the increasing disasters ascribed to a dark wizard, Gellert Grindelwald.
At the same time, by a twist of fate, Newt's precious suitcase will be switched with the identical one of an aspiring No-Maj baker, Jacob Kowalski, while demoted Auror, Tina Goldstein, arrests Newt for being an unregistered wizard.